Stimuli-responsive polymersomes and fluorescent polymersomes

Vous êtes cordialement invités à la conférence de Min-Hui LI, Chimie ParisTech, PSL University Paris, Institut de recherche de Chimie, Paris, organisée par l'Institut Charles Sadron.

Résumé :

Synthetic amphiphilic polymers have been developed since last decades for the purpose of forming self-assembled polymer vesicles (polymersomes), macromolecular analogues of lipid vesicles (liposomes). Polymersomes are much more stable, more robust and less permeable than liposomes due to the high molecular weight of polymers. Another interesting feature of polymersomes is that their properties can be finely adjusted by chemical design of the amphiphilic building blocks. These nanostructures are currently studied as a means of drug delivery and biomedical imaging for their ability to entrap hydrophobic molecules in the membrane and encapsulate hydrophilic ones in the inner aqueous compartment.
Our group has focused, since several years, on the tailor-design of smart polymersomes with biocompatible and biodegradable building blocks, stimuli-responsive release functions and/or aggregation-induced emission (AIE) properties. In this talk, I will first describe some examples of stimuli-responsive polymersomes, such as photo-, reduction- and oxidation-sensitive systems. I will then present our recent efforts at the development of AIE fluorescent polymersomes by combining polymer nanostructures with AIE luminogens (AIEgens) in order to provide innovative approaches to cell/tissue imaging and in vivo study of drug bio-distribution.

Les personnes souhaitant rencontrer Min-Hui Li sont priées de prendre contact avec Marie-Pierre Krafft (tel. 03 88 41 40 60 ou mail : marie-pierre.krafft@ics-cnrs.unistra.fr)