"Flavoenzyme-catalyzed reduction of nitroaromatics and its implications"

Vous êtes cordialement invités à la conférence "Flavoenzyme-catalyzed reduction of nitroaromatics and implications", du Prof. Dr. Narimantas Čėnas, Institute of Biochemistry of Vilnius University, Laboratory of Xenobiotics Biochemistry, Lithuania, organisée par le LIMA

Resumé:

Areas of interest:  the mechanisms of enzymatic reduction of quinones, nitroaromatics, and related compounds by flavoenzymes, their impact on the cytotoxicity/ therapeutic action of the above compounds, the mechanisms of cytotoxicity of polyphenolic antioxidants, bioelectrocatalysis.

Nitroaromatic compounds (annual production 10⁸ t worldwide) comprise an important group of toxic environmental pollutants. On the other hand, their numerous representatives are used as antibacterial, antiparasitic and anticancer agents. The toxic and/or therapeutic action of nitroaromatics stems mainly from their single- and two-electron enzymatic reduction. The aim of this communication is an insight into the following problems: a) mechanism and quantitative structure-activity relationships (QSARs) in single-electron flavoenzyme-catalyzed reduction of nitroaromatics; b) mechanism and QSARs in two-electron enzymatic reduction of nitroaromatics; c) action of nitroaromatics as inhibitors and ‘subversive substrates’ of antioxidant flavoenzymes disulphide reductases, and d) impact of the above mechanisms on the cytotoxic activity of nitroaromatics.