Conférence du Professeur Kalyan Sadhu de l'Université Indian Institute of Technology Roorkee (Inde) organisée par le Laboratoire d'Innovation Moléculaire et Applications (LIMA).
Résumé
Single and double strand DNAs are the next generation storage device. These stands create sophisticated assemblies with variable morphologies, which could be transferred to noble metal nanoparticles. Lu's group have studied the effect of thiol modified single strand DNAs with the same nucleic bases on the different variety of seed morphology to obtain a wide range of nanoarchitectures. Adsorption of amino acids or peptoids onto the surface of gold nanoparticles also leads to a novel route of nanoparticle assemblies with versatile gold nanoarchitectures. We have used the combination of amine modified short single strand DNAs and amino acids or peptides for sequence dependent formation of gold nanoarchitectures. I will discuss our recent studies in the noble metal-based nano-bio interfacial result, where nucleic acids and amino acids have been significantly contributed. We developed aggregation of gold nanoparticle to supra-architecture for supramolecular host-guest chemistry including drug release. Ligand exchange mechanism on gold nanoparticle surface has been utilized for immediate and selective detection of A? monomer at nanomolar concentration. This method motivates us to find cationic fluorophore for A? monomer detection with better sensitive way. In the second part of my talk, I will discuss our journey of finding cationic or neutral fluorophore through air and thermally stable organic radicals